Animal Residue Data Sheet - Quizalofop

Last updated: 4 September 2002

Quizalofop (as either the ethyl or tefuryl esters) is registered in Australia for use on a wide variety of crops including horticultural crops, pulse and legume vegetables, medic pastures and oilseeds. Details of the registered use patterns can be found on the approved labels of registered products containing quizalofop as the active constituent. This Animal Residue Data Sheet provides information on the possible residues in feed commodities obtained from crops treated with quizalofop. It also provides information on the anticipated maximum dietary exposure of animals fed treated commodities, which should not result in the violation of animal MRLs.

Current MRLs

The Australian MRLs for quizalofop in food and animal feed commodities, as listed in Table 1 and Table 4 of the MRL Standard (as at 4 September 2002) are shown below. The MRLs are the same for the two esters. The residue definition of quizalofop ethyl is the sum of quizalofop-ethyl and quizalofop acid and other esters, expressed as quizalofop-ethyl, and the residue definition for quizalofop tefuryl is the sum of quizalofop-p-tefuryl and quizalofop acid, expressed as quizalofop-p-tefuryl.

Code	Food	MRL mg/kg
Food Commodities
VR 0574	Beetroot	0.02
VB 0041	Cabbages, Head	*0.01
VR 0577	Carrot	*0.02
VB 0404	Cauliflower	*0.05
VP 0526	Common bean (pods and/or immature seeds)	*0.02
VC 0424	Cucumber	*0.02
FB 0269	Grapes	*0.02
VC 0046	Melons, except Watermelon	*0.02
VA 0385	Onion, Bulb	*0.02
SO 0697	Peanut	*0.02
FI 0353	Pineapple	*0.05
VR 0589	Potato	*0.01
VD 0070	Pulses	0.2
VC 0429	Pumpkins	*0.02
VR 0494	Radish	*0.02
SO 0495	Rape seed	*0.02
SO 0702	Sunflower seed	*0.05
VO 0448	Tomato	*0.02
Animal commodities
ML 0106	Milks	0.1
MM 0095	Meat [mammalian]	*0.02
MO 0105	Edible offal (Mammalian)	0.2
PM 0110	Poultry meat	*0.05
PO 0111	Poultry, Edible offal of	*0.05
PE 0112	Eggs	*0.02
Animal feed commodities
AL 1023	Clover	2
	Medic pastures	10
AL 1270	Peanut forage (green)	0.5
	Canola forage and fodder	5
	Forage and fodder of soybeans, chickpeas, field peas, lupins, faba beans, mung beans, navy beans and green beans	10

Summary of maximum feeding levels and livestock dietary intakes

The Maximum Feeding Level (MFL, the feeding level at which the MRLs are based), the equivalent Daily Dietary Intake For Livestock (DDIL) and the equivalent daily intake of quizalofop are summarised below.

Species	MFL, ppm in diet	Equivalent DDIL, mg/kg bw	Equivalent intake of quizalofop, mg/animal/day
Cattlea	10	0.30	149.2
Sheepb	10	0.42	25.0
Pigc	10	0.42	25.0
Poultryd	0.5	0.038	0.075
a Based on a actual feeding study data with average feed consumption (15.5 kg DM/day) and average body weights (498 kg) b Based on a cow feeding study and a 60 kg animal consuming 2.5 kg DM/day c Based on a cow feeding study and a 60 kg animal consuming 2.5 kg DM/day d Based on a 2 kg animal consuming 150 g DM/day

Detailed information

All feed commodities

Feed commodities that may contain residues of quizalofop are listed in the table below. The theoretical maximum proportion of the diet that the commodity can comprise, when residues are present at the MRL, without the significant risk of animal commodity MRLs being violated is also given. It should be noted that the feeding levels assumed by the APVMA when setting animal commodity MRLs are theoretical values, and they should not be taken as recommendations of appropriate rations for livestock.

Commodity a	Assumed Maximum proportion of diet (%)b	Feed intake (kg/animal/day)c	MRL (mg/kg) d	Maximum intake of quizalofop from commodity (mg/animal/day)e	Theoretical maximum proportion of diet (%)f
Cattle (Based on a 500 kg animal consuming 20 kg DM/day)
Pastures (medic)	100	20	10	200	100
Clover	100	20	2	40	100
Peanut forage (green)	100	20	0.5	10	100
Canola forage and fodder	100	20	5	100	100
Forage and fodder of pulse and legume vegetables	100	20	10	200	100
Pulses	100	20	0.2	4	100
Oilseeds g	30	6	*0.05	0.3	100
Grape pomace h	20	4	*0.02	0.08	100
Sheep (Based on a 60 kg animal consuming 2.5 kg DM/day)
Pastures (medic)	100	2.5	10	25	100
Clover	100	2.5	2	5	100
Peanut forage (green)	100	2.5	0.5	1.25	100
Canola forage and fodder	100	2.5	5	12.5	100
Forage and fodder of pulse and legume vegetables	100	2.5	10	25	100
Pulses	100	2.5	0.2	0.5	100
Oilseeds g	30	0.75	*0.05	0.038	100
Grape pomace h	20	0.5	*0.02	0.01	100
Pigs (Based on a 60 kg animal consuming 2.5 kg DM/day)
Pulses	100	2.5	0.2	0.5	100
Oilseeds g	30	0.75	*0.05	0.038	100
Grape pomace h	20	0.5	*0.02	0.01	100
Poultry (Based on a 2 kg animal consuming 150 g DM/day)
Pulses	100	0.15	0.2	0.03	100
Oilseeds g	30	0.045	*0.05	0.0023	100
Grape pomace h	20	0.03	*0.02	0.0006	100
a The feed commodities that may contain residues of quizalofop, and may form more than 20% of an animals diet. b The maximum % of the diet that the commodity is assumed to comprise for the purposes of setting MRLs, based on Stockfeed Information Document 1 c The equivalent amount of feed for an animal of designated weight and feed intake that is assumed for the purposes of setting MRLs d The MRL for each feed commodity (correction for dry weight basis where required) e The maximum intake of quizalofop when the commodity is fed at the maximum assumed level (Column 1) in the absence of other sources of quizalofop. f The maximum % of the diet at which the commodity could theoretically be fed without significant risk of exceeding animal commodity MRLs. It is assumed that the residue in the feed commodity is present at the MRL (or dry weight equivalent) and other dietary sources of quizalofop are absent. g Includes oilseed meals and oil. Sunflower seed MRL is shown. No MRLs are set for oilseed meals or oils. h Grape MRL shown. No MRL is established for grape pomace.

Abbreviations and definitions

DM: Dry matter. The feed consumption for livestock and the residue levels in feed commodities are expressed on a dry matter basis.

DDIL: Daily Dietary Intake for Livestock. The level of dietary exposure for a specified chemical in a specified species that should not result in exceedance of the relevant animal commodity MRLs. Expressed in mg chemical/kg bodyweight.

MFL: Maximum Feeding Level. The level of dietary exposure for a specified chemical in a specified species that should not result in exceedance of the relevant animal commodity MRLs. Expressed in terms of ppm in the feed.

MRL: The concentration of a chemical residue, in units of mg/kg, that is legally permitted in or on a food or food commodity.

ppm in the feed: Parts per million in the feed. An alternate way of expressing the level of dietary exposure for a chemical. The level of chemical intake is calculated as though it were present uniformly in the total feed intake. The ppm in the feed is calculated using the following formula: DDIL (mg chemical/kg bw) _ body weight (kg) ¸ daily feed intake (kg).

STMR-P: Supervised Trial Median Residue of the processed commodity. The highest residue that livestock are likely to be exposed to in practice when fed processed commodities over a prolonged period. This is derived from the STMR of the whole commodity multiplied by the processing factor.

Attachment 1: Anticipated maximum dietary exposure

The following calculations outline the theoretical diet used to calculate the maximum anticipated dietary exposure, maximum feeding level (MFL) and the daily dietary intake for livestock (DDIL) for cattle, sheep, pigs and poultry.

Cattle

Feed group	Feed commodity	% in the diet	Feed intake, kg/animal/daya	MRL, mg/kg	% DMb	Intake of quizalofop, mg/animal/dayc
Pastures	Medic pastures	100	20	10		200
	Clover	100	20	2		40
Oilseed crops	Oilseed, meal and oil d	30	6	*0.05		0.3
	Canola forage and fodder	100	20	5		100
	Peanut forage (green)	100	20	0.5		10
Pulse and legumes	Forage and fodder of pulse and legume vegetables	100	20	10		200
	Pulses (grain)	100	20	0.2		4
Grapes	Grape pomace (dry) e	20	4	*0.02		0.08
Total		100	20			200
aBased on assumed feed consumption of 20 kg dry matter/day bEstimate of percentage dry matter. Applied to MRLs expressed on a fresh weight basis cBased on assumed bodyweight of 500 kg dThe MRL for sunflower seed is used in the absence of separate oilseed oil and meal MRLs. eThe grape MRL is used in the absence of a separate grape pomace MRL.

Maximum anticipated dietary exposure:	200 mg/animal/day
equivalent to:	0.40 mg/kg bw
equivalent to:	10 ppm in the diet
MFL (Based on the available animal feeding data (Attachment 2)):	10 ppm in the diet
equivalent DDIL:	0.30 mg/kg bw*

* DDIL based on actual data from animal transfer study

Sheep

Feed group	Feed commodity	% in the diet	Feed intake, kg/animal/daya	MRL, mg/kg	% DMb	Intake of quizalofop, mg/animal/dayc
Pastures	Medic pastures	100	2.5	10		25
	Clover	100	2.5	2		5
Oilseed crops	Oilseed, meal and oil d	30	0.75	*0.05		0.038
	Canola forage and fodder	100	2.5	5		12.5
	Peanut forage (green)	100	2.5	0.5		1.25
Pulse and legumes	Forage and fodder of pulse and legume vegetables	100	2.5	10		25
	Pulses (grain)	100	2.5	0.2		0.5
Grapes	Grape pomace (dry) e	20	0.5	*0.02		0.01
Total		100	2.5			25
aBased on assumed feed consumption of 2.5 kg dry matter/day bEstimate of percentage dry matter. Applied to MRLs expressed on a fresh weight basis cBased on assumed bodyweight of 60 kg dThe MRL for sunflower seed is used in the absence of separate oilseed oil and meal MRLs. eThe grape MRL is used in the absence of a separate grape pomace MRL.

Maximum anticipated dietary exposure:	25 mg/animal/day
equivalent to:	0.42 mg/kg bw
equivalent to:	10 ppm in the diet
MFL (Based on the available animal feeding data (Attachment 2)):	10 ppm in the diet
equivalent DDIL:	0.42 mg/kg bw

Pigs

Feed group	Feed commodity	% in the diet	Feed intake, kg/animal/daya	MRL, mg/kg	% DMb	Intake of quizalofop, mg/animal/dayc
Oilseed crops	Oilseed, meal and oil d	30	0.75	*0.05		0.038
	Pulses (grain)	100	2.5	0.2		0.5
Grapes	Grape pomace (dry) e	20	0.5	*0.02		0.01
Total		100	2.5			0.5
aBased on assumed feed consumption of 2.5 kg dry matter/day bEstimate of percentage dry matter. Applied to MRLs expressed on a fresh weight basis cBased on assumed bodyweight of 60 kg dThe MRL for sunflower seed is used in the absence of separate oilseed oil and meal MRLs. eThe grape MRL is used in the absence of a separate grape pomace MRL.

Maximum anticipated dietary exposure:	0.5 mg/animal/day
equivalent to:	0.0083 mg/kg bw
equivalent to:	0.2 ppm in the diet
MFL (Based on the available animal feeding data (Attachment 2)):	10 ppm in the diet
equivalent DDIL:	0.42 mg/kg bw

Poultry

Feed group	Feed commodity	% in the diet	Feed intake, kg/animal/daya	MRL, mg/kg	% DMb	Intake of quizalofop, mg/animal/dayc
Oilseed crops	Oilseeds, meals and oil d	30	0.045	*0.05		0.0023
	Pulses (grain)	100	0.15	0.2		0.03
Grapes	Grape pomace (dry) e	20	0.03	*0.02		0.0006
Total		100	0.15			0.03
aBased on assumed feed consumption of 0.150 kg dry matter/day bEstimate of percentage dry matter. Applied to MRLs expressed on a fresh weight basis cBased on assumed bodyweight of 2 kg dThe MRL for sunflower seed is used in the absence of separate oilseed oil and meal MRLs. eThe grape MRL is used in the absence of a separate grape pomace MRL.

Maximum anticipated dietary exposure:	0.03 mg/animal/day
equivalent to:	0.015 mg/kg bw
equivalent to:	0.2 ppm in the diet
MFL (Based on the available animal feeding data (Attachment 2)):	0.5 ppm in the diet
equivalent DDIL:	0.038 mg/kg bw