ARDS - Chlorfenapyr

Chlorfenapyr is registered in Australia for use on apples, pears, peaches, Brassica vegetables, Chinese cabbage and cotton. Details of the registered use patterns can be found on the approved labels of registered products containing chlorfenapyr as the active constituent. This Animal Residue Data Sheet provides information on the possible residues in feed commodities obtained from crops treated with chlorfenapyr. It also provides information on the anticipated maximum dietary exposure of animals fed treated commodities, which should not result in the violation of animal MRLs.

Current MRLs

The Australian MRLs for chlorfenapyr in food and animal feed commodities, as listed in Table 1 and Table 4 of the MRL Standard (as at 1 April 2003) are shown below. The residue definition of chlorfenapyr is the parent compound per se.

Code	Food	Current MRL, mg/kg
Food Commodities
VB 0040	Brassica (cole or cabbage) vegetables, Head cabbages, flowerhead brassicas	0.5
VL 0467	Chinese cabbage	0.5
SO 0691	Cotton seed	0.5
FS 0247	Peach	1
FP 0009	Pome fruit	0.5
Animal commodities
MO 0105	Edible offal (mammalian)	*0.05
PE 0112	Eggs	*0.01
MM 0095	Meat (mammalian)[in the fat]	0.05
ML 0106	Milks	*0.01
PO 0111	Poultry, Edible offal of	*0.01
PM 0110	Poultry meat [in the fat]	*0.01
Animal feed commodities
AB 0226	Apple pomace, dry	3

Summary of maximum feeding levels and livestock dietary intakes

The Maximum Feeding Level (MFL, the feeding level at which the MRLs are based), the equivalent Daily Dietary Intake For Livestock (DDIL) and the equivalent daily intake of chlorfenapyr are summarised below.

Species	MFL, ppm in diet	Equivalent DDIL, mg/kg bw	Equivalent intake of chlorfenapyr, mg/animal/day
Cattle^a	0.47	0.019	9.4
Sheep^b	0.47	0.019	1.2
Pig^b	0.47	0.019	1.2
Poultry^c	0.38	0.029	0.057
^a The MFL was determined by extrapolation from the cattle transfer study using results from the group dosed at 0.66 ppm in the diet (0.026 mg/kg bw, 574 kg bw, 22 kg DM/day). The DDIL is calculated from the MFL assuming a 500 kg cow consuming 20 kg DM/day. ^b The MFL is based on cattle data as no sheep or pig data available. The DDIL is calculated from the MFL assuming a 60 kg animal consuming 2.5 kg DM/day ^c The MFL was determined by extrapolation from the poultry metabolism study. The DDIL is calculated from the MFL assuming a 2 kg hen consuming 0.15 kg DM/day.

Detailed information

All feed commodities

Feed commodities that may contain residues of chlorfenapyr are listed in the table below. The theoretical maximum proportion of the diet that the commodity can comprise, when residues are present at the MRL, without the significant risk of animal commodity MRLs being violated is also given. For instance, were apple pomace to be fed to cattle at 30% of the diet, the remainder of the diet would need to be free of residues of chlorfenapyr to minimise the risk of cattle commodity MRLs being violated. It should be noted that the feeding levels assumed by the NRA when setting animal commodity MRLs are theoretical values, and they should not be taken as recommendations of appropriate rations for livestock.

Commodity^a	Assumed Maximum proportion of diet (%)^b	Feed intake (kg/animal/day)^c	MRL (mg/kg)^d	Maximum intake of chlorfenapyr from commodity (mg/animal/day)^e	Theoretical maximum proportion of diet (%)^f
Cattle (Based on a 500 kg animal consuming 20 kg DM/day)
Cotton seed	30	6	0.5	3	90
Apple pomace, dry	20	4	1.44 (STMR-P)	5.8	30
Sheep (Based on a 60 kg animal consuming 2.5 kg DM/day)
Cotton seed	30	0.75	0.5	0.375	90
Apple pomace, dry	20	0.5	1.44 (STMR-P)	0.72	30
Pigs (Based on a 60 kg animal consuming 2.5 kg DM/day)
Cotton seed	30	0.75	0.5	0.375	90
Apple pomace, dry	20	0.5	1.44 (STMR-P)	0.72	30
Poultry (Based on a 2 kg animal consuming 150 g DM/day)
Cotton seed	30	0.045	0.5	0.0225	75
Apple pomace, dry	5	0.0075	1.44 (STMR-P)	0.011	25
^a The feed commodities that may contain residues of chlorfenapyr, and may form more than 20% of an animals diet. ^b The maximum % of the diet that the commodity is assumed to comprise for the purposes of setting MRLs, based on Stockfeed Information Document 1 ^c The equivalent amount of feed for an animal of designated weight and feed intake that is assumed for the purposes of setting MRLs ^d The MRL for each feed commodity (correction for dry weight basis where required) ^e The maximum intake of chlorfenapyr when the commodity is fed at the maximum assumed level (Column 1) in the absence of other sources of chlorfenapyr. ^f The maximum % of the diet at which the commodity could theoretically be fed without significant risk of exceeding animal commodity MRLs. It is assumed that the residue in the feed commodity is present at the MRL (or dry weight equivalent) and other dietary sources of chlorfenapyr are absent.

Abbreviations and definitions

DM: Dry matter. The feed consumption for livestock and the residue levels in feed commodities are expressed on a dry matter basis.

DDIL: Daily Dietary Intake for Livestock. The level of dietary exposure for a specified chemical in a specified species that should not result in exceedance of the relevant animal commodity MRLs. Expressed in mg chemical/kg bodyweight.

MFL: Maximum Feeding Level. The level of dietary exposure for a specified chemical in a specified species that should not result in exceedance of the relevant animal commodity MRLs. Expressed in terms of ppm in the feed.

MRL: The concentration of a chemical residue, in units of mg/kg, that is legally permitted in or on a food or food commodity.

ppm in the feed: Parts per million in the feed. An alternate way of expressing the level of dietary exposure for a chemical. The level of chemical intake is calculated as though it were present uniformly in the total feed intake. The ppm in the feed is calculated using the following formula: DDIL (mg chemical/kg bw) _ body weight (kg) ¸ daily feed intake (kg).

STMR-P: Supervised Trial Median Residue of the processed commodity. The highest residue that livestock are likely to be exposed to in practice when fed processed commodities over a prolonged period. This is derived from the STMR of the whole commodity multiplied by the processing factor.

Attachment 1: Anticipated maximum dietary exposure

The following calculations outline the theoretical diet used to calculate the maximum anticipated dietary exposure, maximum feeding level (MFL) and the daily dietary intake for livestock (DDIL) for cattle, sheep, pigs and poultry.

Cattle

Feed group	Feed commodity	% in the diet	Feed intake, kg/animal/day^a	MRL, mg/kg	% DM^b	Intake of chlorfenapyr, mg/animal/day^c
Oilseeds [30% maximum]	Cotton seed	30	6	0.5	-	3
Fruit by-products [20% maximum]	Apple pomace, dry	20	4	1.44 (STMR-P)	-	5.76
Total		50	10			8.76
^aBased on assumed feed consumption of 20 kg dry matter/day ^bEstimate of percentage dry matter. Applied to MRLs expressed on a fresh weight basis ^cBased on assumed bodyweight of 500 kg

Maximum anticipated dietary exposure:	8.76 mg/animal/day
equivalent to:	0.018 mg/kg bw
equivalent to:	0.44 ppm in the diet

MFL:	0.47 ppm in the diet
equivalent DDIL:	0.019 mg/kg bw

The MFL was determined by extrapolation from the cattle transfer study using results from the group dosed at 0.66 ppm in diet. The DDIL is calculated from the MFL assuming a 500 kg cow consuming 20 kg dry matter per day.

Sheep

Feed group	Feed commodity	% in the diet	Feed intake, kg/animal/day^a	MRL, mg/kg	% DM^b	Intake of chlorfenapyr, mg/animal/day^c
Oilseeds [30% maximum]	Cotton seed	30	0.75	0.5	-	0.375
Fruit by-products [20% maximum]	Apple pomace, dry	20	0.5	1.44 (STMR-P)	-	0.72
Total		50	1.25			1.095
^aBased on assumed feed consumption of 2.5 kg dry matter/day ^bEstimate of percentage dry matter. Applied to MRLs expressed on a fresh weight basis ^cBased on assumed bodyweight of 60 kg

Maximum anticipated dietary exposure:	1.1 mg/animal/day
equivalent to:	0.018 mg/kg bw
equivalent to:	0.44 ppm in the diet

MFL:	0.47 ppm in the diet
equivalent DDIL:	0.019 mg/kg bw

No sheep transfer data are available. The MFL was determined by extrapolation from the cattle transfer study using results from the group dosed at 0.66 ppm in diet. The DDIL is calculated from the MFL assuming a 60 kg sheep consuming 2.5 kg dry matter per day.

Pigs

Feed group	Feed commodity	% in the diet	Feed intake, kg/animal/day^a	MRL, mg/kg	% DM^b	Intake of chlorfenapyr, mg/animal/day^c
Oilseeds [30% maximum]	Cotton seed	30	0.75	0.5	-	0.375
Fruit by-products [20% maximum]	Apple pomace, dry	20	0.5	1.44 (STMR-P)	-	0.72
Total		50	1.25			1.095
^aBased on assumed feed consumption of 2.5 kg dry matter/day ^bEstimate of percentage dry matter. Applied to MRLs expressed on a fresh weight basis ^cBased on assumed bodyweight of 60 kg

Maximum anticipated dietary exposure:	1.1 mg/animal/day
equivalent to:	0.018 mg/kg bw
equivalent to:	0.44 ppm in the diet

MFL:	0.47 ppm in the diet
equivalent DDIL:	0.019 mg/kg bw

No pig transfer data are available. The MFL was determined by extrapolation from the cattle transfer study using results from the group dosed at 0.66 ppm in diet. The DDIL is calculated from the MFL assuming a 60 kg sheep consuming 2.5 kg dry matter per day.

Poultry

Feed group	Feed commodity	% in the diet	Feed intake, kg/animal/day^a	MRL, mg/kg	% DM^b	Intake of chlorfenapyr, mg/animal/day^c
Oilseeds [30% maximum]	Cotton seed	30	0.045	0.5	-	0.0225
Fruit by-products [20% maximum]	Apple pomace, dry	5	0.0075	1.44 (STMR-P)	-	0.0108
Total		35	0.0525			0.0333
^aBased on assumed feed consumption of 0.150 kg dry matter/day ^bEstimate of percentage dry matter. Applied to MRLs expressed on a fresh weight basis ^cBased on assumed bodyweight of 2 kg

Maximum anticipated dietary exposure:	0.033 mg/animal/day
equivalent to:	0.017 mg/kg bw
equivalent to:	0.22 ppm in the diet

MFL:	0.38 ppm in the diet
equivalent DDIL:	0.029 mg/kg bw

The MFL was determined by extrapolation from the poultry metabolism study. The DDIL is calculated from the MFL assuming a 2 kg hen consuming 0.15 kg dry matter per day.