Thiophanate-methyl [dimethyl ((1,2-phenylene)bis(iminocarbonothioyl)) bis(carbamate)] is a systemic benzimidazole fungicide used in Australia to control soil borne diseases in ornamental plants.

Thiophanate-methyl breaks down in plants and the environment to form carbendazim and the use of thiophanate-methyl can lead to residues of carbendazim in treated commodities. For this reason the APVMA is conducting concurrent reviews of carbendazim and thiophanate-methyl.

Thiophanate-methyl review

Status: review completed November 2010

In February 2007 the APVMA began a review of thiophanate-methyl because of occupational health and safety and public health concerns. (Residues were not included in this assessment as there are no products containing thiophanate-methyl that are currently registered for use on food producing plants). This action was based on advice from the Office of Chemical Safety and Environmental Health (OSCEH) (external site) that exposure to carbendazim and compounds that can form it (namely, benomyl and thiophanate-methyl) could possibly cause developmental abnormalities in experimental animals and hence might pose a potential public and occupational health and safety risk.

In August 2010, the APVMA released the Thiophanate-methyl Preliminary Review Findings Report (PDF, 712kb). To minimise the risks to people from the handling and use of thiophanate-methyl, the APVMA proposed amending existing product poison scheduling, label safety directions and re-entry intervals.  In addition, the restraint “NOT FOR HOME GARDEN USE” is required.

Following a period of public consultation, comments were considered and all recommendations proposed in the PRF for thiophanate-methyl were incorporated into the Thiophanate-methyl Final Review Report and Regulatory Decision (released November 2010) (PDF, 743kb). A minor change was made to the restraint “NOT FOR HOME GARDEN USE” to appear as “DO NOT use this product in the home garden”.

Review Report Date
Thiophanate-Methyl Final Review Report and Regulatory Decision (PDF, 743kb) Nov 2010
Gazette Notice: Reconsideration of Active Constituents, Registrations and Label Approvals Related to Thiophanate-methyl (PDF, 45kb) Nov 2010
Thiophanate-methyl Preliminary Review Findings Report (PDF, 725kb) Aug 2010
Thiophanate-methyl Human Health Risk Assessment (PDF, 1.34Mb) Aug 2010
Carbendazim and thiophanate-methyl Scope Document (PDF, 204kb) Feb 2007


For more information contact:

Chemical Review

Phone: +61 2 6210 4749

Fax: +61 2 6210 4776


Product Search

Search the PUBCRIS database for registered products that contain thiophanate-methyl.
Note: In the Active Constituent 1 field enter thiophanate-methyl.

Thiophanate-methyl archive

Title Date
Frequently Asked Questions (updated Nov 2010) Aug 2010
Gazette Notice: Reconsideration of approvals and registrations related to carbendazim Feb 2007
Last updated on 24 March, 2011

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